Treatment of experimental renal osteodystrophy with pamidronate
نویسندگان
چکیده
منابع مشابه
Alkali treatment of renal osteodystrophy.
In 1960 a 5-year-old girl was found to have developed accelerated hypertension (B.P. 190/150) with blood urea 119 mg/ 100 ml. An intravenous pyelogram showed a small scarred left kidney (5-3 by 32 cm). There was also upper pole scarring with clubbed calyces on the right side. Left nephrectomy was performed and histological examination of the kidney confirmed pyelonephritic changes, and showed i...
متن کاملPathogenesis and treatment of renal osteodystrophy.
Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease. The main two conditions are osteitis fibrosa, characterized by high bone turnover, increased osteoclastic and osteoblastic activity, and high levels of circulating parathyroid hormone (PTH) and adynamic bone disease characterized by low ...
متن کاملRenal osteodystrophy.
The incidence of chronic renal disease is increasing, and the pattern of renal osteodystrophy seems to be shifting from the classic hyperparathyroid presentation to one of low bone turnover. Patients with persistent disease also live longer than previously and are more physically active. Thus, patients may experience trauma as a direct result of increased physical activity in a setting of weake...
متن کاملHepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment
OBJECTIVES: The present study was designed to evaluate the bone phenotypes and mechanisms involved in bone disorders associated with hepatic osteodystrophy. Hepatocellular disease was induced by carbon tetrachloride (CCl4). In addition, the effects of disodium pamidronate on bone tissue were evaluated. METHODS: The study included 4 groups of 15 mice: a) C = mice subjected to vehicle injection...
متن کاملEffects of treatment of renal osteodystrophy on bone histology.
Renal osteodystrophy is characterized by abnormalities in bone turnover, mineralization, and bone volume. The effects of treatment modalities for renal osteodystrophy on bone should be analyzed with respect to these abnormalities. The major treatment modalities for renal osteodystrophy include phosphate binders, vitamin D compounds, and calcimimetics. Aluminum-containing phosphate binders have ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/ki.2008.180